In which condition is angular cheilitis commonly observed?

Angular cheilitis is often observed in both erythema multiforme and Plummer-Vincent syndrome. This condition is characterized by inflammation and cracking at the corners of the mouth, which can result from a variety of underlying health issues.

In erythema multiforme, a hypersensitivity reaction often triggered by infections or medications, angular cheilitis can occur as a result of the overall inflammatory process affecting the mucocutaneous areas, particularly the lips and corners of the mouth.

On the other hand, Plummer-Vincent syndrome, which involves iron deficiency anemia and may present with symptoms such as dysphagia (difficulty swallowing), is also associated with angular cheilitis. The nutritional deficiencies that characterize this syndrome, particularly deficiencies in iron, folate, or vitamins, may lead to changes in the mucosa, predisposing individuals to angular cheilitis.

Therefore, since angular cheilitis may appear in both of these conditions, the answer encompasses both, demonstrating that it is not limited to a single etiology but instead may reflect broader systemic issues relating to inflammation or nutritional deficiency.