What is a common side effect of long-term use of Tetracycline?

Tooth discoloration is a well-documented side effect of long-term use of Tetracycline antibiotics. This occurs because Tetracycline has a tendency to bind to calcium ions and deposit in developing teeth. As a result, individuals who have taken Tetracycline during childhood or during periods when teeth are still developing may experience yellow, gray, or brown discoloration of their teeth. This impact is particularly significant for children under the age of eight and pregnant women as it can affect developing enamel in infants.

While the other options mentioned can be associated with various medications or health conditions, they are not specifically tied to the long-term use of Tetracycline in the same way that tooth discoloration is. Understanding the specific side effects associated with medications is crucial for patient care, particularly in the context of teeth and oral health, where Tetracycline can have a lasting effect.