Which characteristic is TRUE regarding osteogenesis imperfecta?

Osteogenesis imperfecta is indeed associated with deafness. This condition, often known as "brittle bone disease," affects the production of collagen, which is vital for the strength and structure of bones. The abnormal collagen not only leads to weakened bones that are prone to fractures but can also impact the ossicles in the ear, which can lead to hearing loss in affected individuals. It's important to note that while the other options touch on aspects of osteogenesis imperfecta or similar conditions, they don’t accurately represent the characteristics of the disorder.

For instance, the manifestation of blue sclera is a common feature, but it is one of several possible indicators rather than universally true for all cases. The notion that it's a sex-linked disorder is incorrect as osteogenesis imperfecta typically follows an autosomal dominant inheritance pattern, affecting both sexes equally. Lastly, while fractures can occur before birth, this is not a common characteristic and does not define the disorder. Thus, the association of osteogenesis imperfecta with deafness stands out as a reliable characteristic.