Which syndrome is associated with children born with cleft palate, microdontia and glossoptosis?

Cleft palate, microdontia, and glossoptosis are hallmark features of Pierre-Robin Syndrome. This condition is characterized primarily by the triad of micrognathia (a small jaw), glossoptosis (downward displacement or retraction of the tongue), and cleft palate. The presence of these features stems from developmental issues in the first and second branchial arches during embryonic formation.

In Pierre-Robin Syndrome, the underdeveloped jaw can lead to a range of feeding difficulties, and the positioning of the tongue may obstruct the airway, which is also significant when it comes to the management of these patients. The association of microdontia, or smaller than normal teeth, further supports the diagnosis.

Other syndromes listed may have overlapping features with some aspects of facial deformities or clefts, but they do not specifically encapsulate the combination of cleft palate, microdontia, and glossoptosis in the same manner as Pierre-Robin Syndrome.